Itai no wa Iya nano de Bougyoryoku ni Kyokufuri Shitai to Omoimasu follows the story of Kaede Honjou, who, after being persuaded by her friend, starts playing a VRMMORPG game. To avoid pain, she heavily invests her points in defense, leading to unexpected results. As she navigates through the game, she discovers unique ways to utilize her abilities. The series explores themes of friendship, adventure, and the unpredictability of online gaming.