Fullmetal Alchemist, originally titled 'Hagane no Renkinjutsushi', is a popular anime series based on the manga by Hiromu Arakawa. It follows the story of two brothers, Edward and Alphonse Elric, who use alchemy in their quest to find the Philosopher's Stone to restore their bodies after a failed alchemical experiment. The series is renowned for its rich storytelling, complex characters, and exploration of themes like sacrifice and redemption.