Xenosaga: The Animation is an anime adaptation of the Xenosaga video game series, specifically covering the events of the first game, Xenosaga Episode I: Der Wille zur Macht. The story follows Shion Uzuki and her encounters with the mysterious KOS-MOS android as they navigate conflicts between various factions in a futuristic universe. The series explores deep themes of philosophy and human existence, maintaining the narrative depth of its source material.