Futakoi is a romantic comedy anime series that follows the story of a young boy named Nozomu Futami, who returns to his hometown and finds himself surrounded by multiple sets of identical twin sisters. Each pair of twins has their own distinct personalities and interests, leading to a series of comedic and heartwarming situations as Nozomu navigates his interactions with them. The series explores themes of friendship, love, and growing up in a lighthearted manner.