Irohanihoheto is an anime series set during the Bakumatsu era, a period of civil unrest in Japan. The story follows Akizuki Youjirou, a lone samurai on a mission to prevent an ancient artifact from causing further chaos. Along the way, he crosses paths with a traveling theater troupe, and together they navigate the turbulent political landscape of the time. The series blends historical events with supernatural elements, creating a captivating narrative.