Tomo-chan wa Onnanoko! is a romantic comedy anime centered around Tomo Aizawa, a tomboyish high school girl who struggles to convey her romantic feelings to her childhood friend, Junichirou Kubota. The series humorously explores their friendship and Tomo's efforts to express her femininity, despite being viewed as 'one of the guys' by Jun. Throughout the series, Tomo navigates her emotions and the challenges of adolescence with the help of her friends. The anime is beloved for its charming characters and lighthearted storytelling.