Tasogare Otome x Amnesia is a supernatural mystery anime series that follows Teiichi Niiya, a high school student who encounters the ghost of a girl named Yuuko Kanoe. Together, they unravel the secrets of the school's haunted past and Yuuko's mysterious death. The series combines elements of horror, romance, and comedy, providing a unique and engaging storyline. It explores themes of memory, loss, and the supernatural, captivating audiences with its eerie yet touching narrative.