s-CRY-ed is an action-packed anime series set in a future where a mysterious earthquake has created an isolated area called the Lost Ground. Within this area, individuals known as 'Alter users' possess the ability to manipulate matter. The story follows Kazuma and Ryuho, two powerful Alter users with opposing ideals, as they clash in a battle for freedom and control. The series explores themes of identity, power, and the consequences of unchecked ambition.