Oniichan no Koto nanka Zenzen Suki Janain Dakara ne!! is a comedic anime series that explores the complicated dynamics of sibling relationships. The story revolves around a girl named Nao who has a deep, yet awkward, affection for her older brother Shuusuke. Despite her outward denial, her actions often contradict her words, leading to humorous situations. The series delves into themes of family, love, and the challenges of adolescence.