Comic Girls is a slice-of-life anime series centered on the lives of four female manga artists living together in a dormitory. The main character, Kaoruko Moeta, struggles with her confidence and drawing skills, but finds support and friendship among her fellow dorm mates. As they work on their respective manga projects, they navigate the challenges of creativity, deadlines, and personal growth. The series offers a lighthearted look into the world of manga creation, filled with humor and heartwarming moments.