Ena Ayase is a character from the manga series 'Yotsuba to!' created by Kiyohiko Azuma. She is a young girl who lives next door to the main protagonist, Yotsuba Koiwai. Ena is known for her kind and gentle nature, often acting as a big sister figure to Yotsuba. Despite her young age, she is quite responsible and mature, often helping her mother with chores and taking care of her dog, Juliet. Ena's interactions with Yotsuba add depth to the series, showcasing themes of friendship and innocence.