Helena Harper is a central character in the video game Biohazard 6, known as Resident Evil 6 in the West. She is a skilled agent working for the United States Secret Service. Helena becomes entangled in the viral outbreak when she is framed for the assassination of the President. Throughout the game, she partners with Leon S. Kennedy, striving to uncover the truth behind the bioterror attack. Helena is driven by a deep sense of guilt and a desire to protect her sister, Deborah, who becomes a tragic victim of the viral chaos.