Ishizu Ishtar is a significant supporting character in the anime series 'Yu-Gi-Oh! Duel Monsters.' She is a member of the Ishtar family, the guardians of the Millennium Items, and serves as the curator of the Domino Museum. Ishizu is known for her calm and wise demeanor, as well as her deep sense of duty to protect the world from the Millennium Items' dark power. She plays a pivotal role in the Battle City arc, guiding Yugi and his friends with her insights and ancient knowledge.