Mega Drive is one of the three main characters in the anime series Hi☆sCoool! SeHa Girls, which anthropomorphizes classic Sega gaming consoles as students attending a school inside the Sega building. Mega Drive is depicted as a calm, intelligent, and somewhat mature character, reflecting the reputation of the original Sega Mega Drive console. She often serves as the voice of reason among the group and is deeply knowledgeable about games, contributing valuable insights and support to her friends in their adventures.